Renal tubular secretion of potassium in the normal dog.
نویسندگان
چکیده
During the administration ofsalyrgant (sodium salt of mercury salicyl-allylamide-ortho-acetate) to dogs, it was observed that the rate of potassium excretion frequently became constant and remained at a fixed level despite marked changes in the calculated rate ofpotassium filtration at the glomerulus. A constant excretory rate dissociated from filtered load is strongly suggestive of a tubular secretory mechanism. Such a mechanism for the addition of potassium to the tubular urine has, in fact, been demonstrated in the dog by experiments to be described. Material and Methods. Experiments were performed on 4 trained, unanesthetized female dogs. To obtain stable plasma creatinine and inulin concentrations and to assure constant rates of potassium intake; solutions were administered by continuous infusion. Urine and heparinized venous blood samples were collected by the usual techniques for the determination of clearances. The plasma creatinine clearance was used as a measure of glomerular filtration rate. The equivalence of the creatinine clearance and filtration rate in the dog is generally accepted. In 2 experiments inulin clearances were simultaneously determined to check on the validity of the creatinine clearance as a measure of filtration rate under the circumstances of these experiments. Creatinine was determined in tungstic acid filtrates of plasma and in diluted urine by a modification of the Folin method.1 Inulin was determined by a modification of Harrison’s method.2 Both plasma and urine were treated with yeast before precipitation with zinc.
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Distal Renal Tubular Acidosis with Grade 4 Vesicoureteral Reflux in a Child with Single Kidney
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Renal tubular acidosis (RTA) is a non-uremic defects of urinary acidification. It is characterized by a normal anion gap hyperchloremic metabolic acidosis; plasma potassium may be normal, low or highdepending on the type of RTA. These syndromes differ from uremic acidosis which is associated with a high anion gap, decreased glomerular filtration with enhanced proton secretion by the remaining n...
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عنوان ژورنال:
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
دوره 67 4 شماره
صفحات -
تاریخ انتشار 1948